What should be done if a mouse is unusually fat? - briefly
Evaluate the mouse’s condition, reduce caloric intake, and increase physical activity; if health concerns persist, seek veterinary assessment.
What should be done if a mouse is unusually fat? - in detail
If a laboratory or pet mouse shows signs of excessive adiposity, immediate assessment and corrective measures are required to prevent health complications.
First, verify the condition. Weigh the animal using a calibrated balance, compare the result with the species‑specific reference range for its age, sex, and strain. Observe for additional indicators such as reduced activity, respiratory difficulty, or skin folds that impede normal movement. Document the findings in the animal’s record.
Next, examine the diet. Identify the current feed formulation, feeding schedule, and any supplemental treats. Reduce caloric density by switching to a maintenance‑level chow, eliminating high‑fat supplements, and limiting treat frequency to no more than 5 % of total caloric intake. Ensure the feed is fresh and stored properly to avoid spoilage that could affect palatability and intake.
Adjust the environment to promote physical activity. Provide enrichment items such as running wheels, tunnels, and climbing structures. Increase cage space if possible, and schedule daily handling sessions that encourage movement. Monitor activity levels for at least one week to gauge response.
Implement a health monitoring plan. Record body weight weekly, noting any trend toward stabilization or loss. Conduct a brief physical examination every two weeks, checking for signs of hepatic lipidosis, glucose intolerance, or musculoskeletal stress. If weight loss exceeds 10 % of body mass within a short period, reassess feeding protocol to avoid undernutrition.
Consider veterinary consultation when:
- Weight exceeds 20 % above the normal range for the specific strain.
- The mouse displays lethargy, dyspnea, or skin lesions.
- Blood chemistry reveals elevated triglycerides, cholesterol, or liver enzymes.
The veterinarian may recommend diagnostic tests such as serum biochemistry, glucose tolerance testing, or imaging to rule out underlying endocrine disorders. Pharmacologic interventions, such as metformin, are reserved for confirmed metabolic dysfunction and should be administered under professional guidance.
Finally, maintain accurate records of all interventions, observations, and outcomes. This documentation supports reproducibility in research settings and ensures proper care in domestic environments.