Why are white mice used in laboratories? - briefly
White laboratory mice are preferred because their uniform coat simplifies genetic monitoring and reduces experimental variability. Their well‑characterized genome, rapid breeding cycle, and low cost further support their widespread use.
Why are white mice used in laboratories? - in detail
White laboratory mice are preferred because they provide a consistent biological platform that reduces experimental variability. Their genetic background is well characterized, allowing researchers to attribute observed effects to specific interventions rather than unknown genetic differences.
- Inbred strains produce offspring that are genetically identical, which simplifies data interpretation.
- The albino phenotype offers a uniform coat color, facilitating visual assessments, imaging techniques, and automated tracking systems.
- High reproductive rates and short gestation periods enable rapid generation of large sample sizes.
- Standardized diet, housing, and handling protocols have been established for these animals, minimizing external influences on experimental outcomes.
- Extensive historical data exist for these strains, allowing comparison with published results and meta‑analyses.
The ease of genetic manipulation further enhances their utility. Techniques such as transgenesis, knockout, and CRISPR editing have been optimized for these mice, producing models that mimic human diseases with precision. Their small size reduces the amount of reagents required and lowers housing costs, making large‑scale studies economically feasible.
Regulatory agencies and institutional animal care committees recognize these strains as accepted models, streamlining approval processes. Consequently, white laboratory mice represent a reliable, cost‑effective, and ethically manageable choice for a wide range of biomedical research applications.