"Researcher" - what is it, definition of the term
An investigator who systematically studies biological phenomena uses rats and mice as model organisms to generate reproducible data, designs experiments, collects and analyzes results, and disseminates findings through peer‑reviewed channels.
Detailed information
Scientists who study rodents such as rats and mice design experiments to uncover physiological, genetic, and behavioral mechanisms. Their work begins with selecting appropriate species and strains, considering factors like lifespan, breeding characteristics, and relevance to human conditions. Laboratory colonies are maintained under controlled temperature, humidity, and light cycles to ensure reproducibility.
Experimental protocols specify housing conditions, enrichment items, and feeding regimens. Researchers record baseline metrics—body weight, activity levels, and metabolic rates—before introducing interventions. Interventions may include pharmacological agents, gene editing techniques, or environmental manipulations. Data collection employs tools such as telemetry devices, video tracking systems, and electrophysiological recordings.
Ethical oversight is mandatory. Institutional committees evaluate study designs for humane treatment, justification of animal numbers, and adherence to the 3Rs principle—replacement, reduction, and refinement. Pain mitigation strategies involve anesthetics, analgesics, and postoperative monitoring.
Statistical analysis follows predefined plans. Sample size calculations account for expected effect sizes and variability within rodent populations. Results are reported with confidence intervals, effect sizes, and p‑values, enabling comparison across studies.
Key responsibilities of the investigator include:
- Designing reproducible experiments that align with scientific objectives.
- Maintaining colony health through regular health checks and quarantine procedures.
- Ensuring accurate documentation of all procedures, observations, and deviations.
- Communicating findings through peer‑reviewed publications and conference presentations.
Through meticulous planning, rigorous methodology, and compliance with ethical standards, these professionals generate insights that advance biomedical research and inform therapeutic development.