How do you split tablets for rats? - briefly
Use a precision tablet cutter or a clean razor blade to halve the tablet, then verify the dose by weighing each half; if a smaller fraction is needed, crush the tablet and measure the exact portion with a microbalance.
How do you split tablets for rats? - in detail
When a medication is supplied in tablet form but the required dose for a rat is smaller, the tablet must be divided accurately to avoid under‑ or overdosing. The process involves three essential stages: preparation, division, and verification.
First, gather a clean, flat surface, a sharp blade or a tablet splitter designed for small doses, a precision scale (sensitivity of 0.001 g), and a disposable glove. Clean the tablet with a dry tissue to remove any powder that could affect the cut.
Second, calculate the exact fraction needed. For example, a 100 mg tablet prescribed at 2 mg per rat requires a 1/50 portion. Use the scale to confirm the tablet’s weight, then mark the tablet at the calculated division point. If the tablet is scored, align the blade with the score line; if not, apply gentle pressure with a clean razor blade, ensuring the cut passes through the center to produce equal halves, then repeat for quarters, eighths, etc., until the desired fraction is achieved.
Third, verify the split portion by weighing it on the precision scale. Adjust by trimming excess material if the measured weight deviates by more than 5 % from the target dose. Once the correct fragment is isolated, place it in a pre‑weighed micro‑tube, add a measured volume of water or appropriate vehicle, and vortex to create a homogeneous suspension. Administer the suspension to the rat using a calibrated oral gavage needle or a small syringe.
Key considerations:
- Use a fresh blade for each tablet to prevent cross‑contamination.
- Store remaining tablet fragments in a labeled, airtight container at the recommended temperature.
- Document the original tablet strength, calculated fraction, measured weight, and administration time for each animal.
Following these steps ensures precise dosing, minimizes waste, and maintains the integrity of the medication when administered to rodents.