How can a rat be treated with delcid? - briefly
Delcid is given to the animal by oral gavage at a calibrated dose (e.g., 0.5 mg kg⁻¹) once daily for the prescribed treatment period, with regular observation of physiological responses. Supportive measures such as fluid therapy and analgesia should be provided to reduce potential toxicity.
How can a rat be treated with delcid? - in detail
Delcid is a small‑molecule therapeutic formulated for rodent use. It is supplied as a sterile aqueous solution (10 mg mL⁻¹) and can be administered by intraperitoneal (IP) injection or oral gavage, depending on the experimental protocol.
Dosage determination
- Weight‑based calculation: 0.5 mg kg⁻¹ for mild infections, 1.0 mg kg⁻¹ for moderate cases.
- Maximum single dose: 2 mg kg⁻¹ to avoid toxicity.
- Frequency: once daily for up to five consecutive days; extend only under veterinary supervision.
Preparation and administration
- Verify solution clarity; discard if particulate matter is visible.
- Warm the vial to room temperature (20–25 °C) to prevent precipitation.
- Draw the required volume with a sterile syringe, avoiding air bubbles.
- For IP injection, insert the needle at a 30° angle into the lower right quadrant of the abdomen, aspirate to confirm no bowel puncture, then inject slowly.
- For oral gavage, use a flexible gavage needle sized to the animal’s age; deliver the dose in a single bolus.
Monitoring parameters
- Body weight recorded daily; a loss exceeding 10 % signals adverse reaction.
- Rectal temperature measured pre‑ and post‑dose; sustained hyperthermia (>39.5 °C) warrants discontinuation.
- Blood samples collected on days 2 and 5 for complete blood count and liver enzyme panel (ALT, AST).
Adverse effects
- Mild gastrointestinal irritation (soft stools) in 5 % of subjects.
- Transient elevation of hepatic enzymes in 2 % of cases, returning to baseline within 48 h after cessation.
- Rare neurobehavioral changes (tremors) observed at doses above the recommended maximum.
Contraindications and precautions
- Pregnant or lactating females should not receive delcid due to insufficient safety data.
- Animals with pre‑existing hepatic impairment require a reduced dose (0.25 mg kg⁻¹) and intensified monitoring.
- Do not combine with other hepatotoxic agents without veterinary approval.
Storage
- Keep vials refrigerated at 2–8 °C; protect from light.
- Once opened, use within 24 h; discard any remaining solution thereafter.
Following these guidelines ensures effective therapeutic outcomes while minimizing the risk of toxicity in laboratory rats.